D-(+)-Trehalose dihydrate 97.0-102.0% (by anhydrous basis) Ph. Eur., NF for bioprocessing, suitable for use as excipient endotoxin tested

3599.0100EA 203 EUR
3599.0100 3599.9025 3599.1000 3599.5000
D-(+)-Trehalose dihydrate 97.0-102.0% (by anhydrous basis) Ph. Eur., NF for bioprocessing, suitable for use as excipient endotoxin tested
D-(+)-Trehalose dihydrate

D-Trehalose is a non-reducing homodisaccharide found in both higher and lower life forms, but not Mammalians. Its role is thought to prevent protein denaturation under stress. This phenomena has led to trehalose’s use in protein stabilization during freeze drying.
VWR St. Louis manufactured D-Trehalose meets the customers’ needs in several ways:


  • GMP manufactured material
  • Available in Bulk packaging
  • Quality at or above the regulatory demands in the FDA Audited facility
  • Transparency throughout the supply chain
  • BSE/TSE Free, as it originates from a plant source

Formula: C₁₂H₂₂O₁₁·2H₂O
MW: 378,33 g/mol
MDL Number: MFCD00071594
CAS Number: 6138-23-4
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Specification Test Results

Assay (calculated on anhydrous) 97,0 - 102,0%
Appearance White or almost white crystalline powder
Identification A (IR) Passes test
Identification B Passes test
Identification C Passes test
Appearance of solution Passes test Ph. Eur.
Clarity and colour of solution Passes test NF
pH (10% W/V) 4,5 - 6,5
Spec. opt. rot. (20 °C) (on anhydrous) 197 - 201°
Glucose Max. 0,5%
Oligosaccharides Max. 0,5%
Unspecified impurities Max. 0,2%
Total impurities Max. 1,0%
Heavy metals (as Pb) [NF] Max. 5 ppm
Cl (Chloride) [NF] Max. 0,0125%
Cl (Chloride) [Ph. Eur.] Max. 125 ppm
SO₄ (Sulphate) [NF] Max. 0,0200%
SO₄ (Sulphate) [Ph. Eur.] Max. 200 ppm
N (Nitrogen) [NF] Max. 0,005%
Soluble starch Passes test NF
Soluble starch Passes test Ph. Eur.
Water Max. 11,0%
Sulphated ash Max. 0,1%
Residual solvents (Ethanol) Max. 5000 ppm
Residual solvents (Methanol) Max. 3000 ppm
Residual solvents (MIBK) Max. 5000 ppm
Bacterial endotoxins Max. 2,5 EU/mg
Escherichia coli Absent
Salmonella Absent
TAMC Max. 100 CFU/g
TYMC Max. 100 CFU/g
Conforms to NF/Ph. Eur. Passes test

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