Size exclusion analysis of mAbs: advanced detection - advanced columns
Monoclonal antibodies (mAbs) are routinely analyzed by size exclusion chromatography to detect high and low molecular weight impurities (mAb aggregates or fragments). Predominantly, UV absorbance is used for detection. However, advanced detection technologies namely multiangle light scattering (MALS) and mass spectrometry (MS) better characterize mAbs and reveal species hidden in UV chromatograms. This webinar will explain the different detection methods and their results. Special emphasis will be placed on the higher requirements for size exclusion columns preceding advanced detection methods.
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